Protocadherin gamma-A3 (PCDHGA3)
Homo sapiens — UniProt Q9Y5H0
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin gamma-A3 (PCDHGA3) is a protein from Homo sapiens identified by UniProt accession Q9Y5H0, 932 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q9Y5H0; gene symbol PCDHGA3.
- Organism: Homo sapiens.
- Length: 932 amino acids.
- Top disease associations (Open Targets): genetic disorder, Neurodevelopmental disorder and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin gamma-A3 |
|---|---|
| UniProt accession | Q9Y5H0 |
| Gene | PCDHGA3 |
| Organism | Homo sapiens |
| Length | 932 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.19
- Neurodevelopmental disorder · score 0.12
- mean platelet volume · score 0.10
- self reported educational attainment · score 0.04
- refractive error measurement · score 0.02
- neoplasm · score 0.01
- Stroke · score 0.01
- triple-negative breast cancer · score 0.01
- endometrial carcinoma · score 0.01
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5H0-F1 | alphafold | PREDICTED | 74.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5H0.
Amino-acid sequence (932 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHGA3?
The strongest Open Targets associations for PCDHGA3 are genetic disorder, Neurodevelopmental disorder, mean platelet volume, self reported educational attainment and refractive error measurement.
How long is the PCDHGA3 protein?
The Homo sapiens PCDHGA3 protein (UniProt Q9Y5H0) is 932 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5H0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5H0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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