Protocadherin alpha-8 (PCDHA8)
Homo sapiens — UniProt Q9Y5H6
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin alpha-8 (PCDHA8) is a protein from Homo sapiens identified by UniProt accession Q9Y5H6, 950 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9Y5H6; gene symbol PCDHA8.
- Organism: Homo sapiens.
- Length: 950 amino acids.
- Top disease associations (Open Targets): Thrombocytosis, Hirschsprung disease and prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin alpha-8 |
|---|---|
| UniProt accession | Q9Y5H6 |
| Gene | PCDHA8 |
| Organism | Homo sapiens |
| Length | 950 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- Thrombocytosis · score 0.12
- Hirschsprung disease · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- depressive symptom measurement · score 0.11
- schizophrenia · score 0.10
- unipolar depression · score 0.10
- vital capacity · score 0.09
- forced expiratory volume · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5H6-F1 | alphafold | PREDICTED | 73.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5H6.
Amino-acid sequence (950 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHA8?
The strongest Open Targets associations for PCDHA8 are Thrombocytosis, Hirschsprung disease, prostate cancer, Familial prostate cancer and prostate carcinoma.
How long is the PCDHA8 protein?
The Homo sapiens PCDHA8 protein (UniProt Q9Y5H6) is 950 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5H6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5H6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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