Protocadherin alpha-5 (PCDHA5)
Homo sapiens — UniProt Q9Y5H7
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin alpha-5 (PCDHA5) is a protein from Homo sapiens identified by UniProt accession Q9Y5H7, 936 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9Y5H7; gene symbol PCDHA5.
- Organism: Homo sapiens.
- Length: 936 amino acids.
- Top disease associations (Open Targets): Thrombocytosis, prostate carcinoma and Hirschsprung disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin alpha-5 |
|---|---|
| UniProt accession | Q9Y5H7 |
| Gene | PCDHA5 |
| Organism | Homo sapiens |
| Length | 936 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- Thrombocytosis · score 0.12
- prostate carcinoma · score 0.11
- Hirschsprung disease · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- schizophrenia · score 0.10
- self reported educational attainment · score 0.09
- cognitive function measurement · score 0.09
- depressive symptom measurement · score 0.09
- systolic blood pressure · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5H7-F1 | alphafold | PREDICTED | 74.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5H7.
Amino-acid sequence (936 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHA5?
The strongest Open Targets associations for PCDHA5 are Thrombocytosis, prostate carcinoma, Hirschsprung disease, prostate cancer and Familial prostate cancer.
How long is the PCDHA5 protein?
The Homo sapiens PCDHA5 protein (UniProt Q9Y5H7) is 936 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5H7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5H7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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