Protocadherin alpha-3 (PCDHA3)
Homo sapiens — UniProt Q9Y5H8
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin alpha-3 (PCDHA3) is a protein from Homo sapiens identified by UniProt accession Q9Y5H8, 950 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9Y5H8; gene symbol PCDHA3.
- Organism: Homo sapiens.
- Length: 950 amino acids.
- Top disease associations (Open Targets): depressive symptom measurement, unipolar depression and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin alpha-3 |
|---|---|
| UniProt accession | Q9Y5H8 |
| Gene | PCDHA3 |
| Organism | Homo sapiens |
| Length | 950 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- depressive symptom measurement · score 0.23
- unipolar depression · score 0.21
- schizophrenia · score 0.20
- body mass index · score 0.15
- self reported educational attainment · score 0.15
- cognitive function measurement · score 0.15
- vital capacity · score 0.14
- forced expiratory volume · score 0.13
- body weight · score 0.12
- intelligence · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5H8-F1 | alphafold | PREDICTED | 73.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5H8.
Amino-acid sequence (950 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHA3?
The strongest Open Targets associations for PCDHA3 are depressive symptom measurement, unipolar depression, schizophrenia, body mass index and self reported educational attainment.
How long is the PCDHA3 protein?
The Homo sapiens PCDHA3 protein (UniProt Q9Y5H8) is 950 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5H8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5H8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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