Protocadherin alpha-2 (PCDHA2)
Homo sapiens — UniProt Q9Y5H9
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin alpha-2 (PCDHA2) is a protein from Homo sapiens identified by UniProt accession Q9Y5H9, 948 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9Y5H9; gene symbol PCDHA2.
- Organism: Homo sapiens.
- Length: 948 amino acids.
- Top disease associations (Open Targets): depressive symptom measurement, unipolar depression and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin alpha-2 |
|---|---|
| UniProt accession | Q9Y5H9 |
| Gene | PCDHA2 |
| Organism | Homo sapiens |
| Length | 948 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- depressive symptom measurement · score 0.17
- unipolar depression · score 0.16
- schizophrenia · score 0.14
- Thrombocytosis · score 0.12
- prostate carcinoma · score 0.11
- Hirschsprung disease · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- myeloid white cell count · score 0.11
- neutrophil count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5H9-F1 | alphafold | PREDICTED | 73.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5H9.
Amino-acid sequence (948 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHA2?
The strongest Open Targets associations for PCDHA2 are depressive symptom measurement, unipolar depression, schizophrenia, Thrombocytosis and prostate carcinoma.
How long is the PCDHA2 protein?
The Homo sapiens PCDHA2 protein (UniProt Q9Y5H9) is 948 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5H9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5H9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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