Protocadherin alpha-11 (PCDHA11)
Homo sapiens — UniProt Q9Y5I1
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin alpha-11 (PCDHA11) is a protein from Homo sapiens identified by UniProt accession Q9Y5I1, 949 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9Y5I1; gene symbol PCDHA11.
- Organism: Homo sapiens.
- Length: 949 amino acids.
- Top disease associations (Open Targets): Hirschsprung disease, vital capacity and granulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin alpha-11 |
|---|---|
| UniProt accession | Q9Y5I1 |
| Gene | PCDHA11 |
| Organism | Homo sapiens |
| Length | 949 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- Hirschsprung disease · score 0.11
- vital capacity · score 0.07
- granulocyte count · score 0.07
- sum of neutrophil and eosinophil counts · score 0.06
- neutrophil count · score 0.05
- myeloid white cell count · score 0.05
- sum of basophil and neutrophil counts · score 0.05
- Abnormality of refraction · score 0.05
- forced expiratory volume · score 0.03
- Ataxia-telangiectasia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5I1-F1 | alphafold | PREDICTED | 73.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5I1.
Amino-acid sequence (949 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHA11?
The strongest Open Targets associations for PCDHA11 are Hirschsprung disease, vital capacity, granulocyte count, sum of neutrophil and eosinophil counts and neutrophil count.
How long is the PCDHA11 protein?
The Homo sapiens PCDHA11 protein (UniProt Q9Y5I1) is 949 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5I1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5I1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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