Protocadherin alpha-1 (PCDHA1)
Homo sapiens — UniProt Q9Y5I3
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin alpha-1 (PCDHA1) is a protein from Homo sapiens identified by UniProt accession Q9Y5I3, 950 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9Y5I3; gene symbol PCDHA1.
- Organism: Homo sapiens.
- Length: 950 amino acids.
- Top disease associations (Open Targets): depressive symptom measurement, unipolar depression and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin alpha-1 |
|---|---|
| UniProt accession | Q9Y5I3 |
| Gene | PCDHA1 |
| Organism | Homo sapiens |
| Length | 950 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- depressive symptom measurement · score 0.21
- unipolar depression · score 0.20
- schizophrenia · score 0.19
- Thrombocytosis · score 0.12
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Hirschsprung disease · score 0.11
- self reported educational attainment · score 0.10
- cognitive function measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5I3-F1 | alphafold | PREDICTED | 73.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5I3.
Amino-acid sequence (950 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHA1?
The strongest Open Targets associations for PCDHA1 are depressive symptom measurement, unipolar depression, schizophrenia, Thrombocytosis and Familial prostate cancer.
How long is the PCDHA1 protein?
The Homo sapiens PCDHA1 protein (UniProt Q9Y5I3) is 950 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5I3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5I3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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