Claudin-16 (CLDN16)
Homo sapiens — UniProt Q9Y5I7
Data last refreshed: (UniProt release unknown)
Key facts
Claudin-16 (CLDN16) is a protein from Homo sapiens identified by UniProt accession Q9Y5I7, 235 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: Q9Y5I7; gene symbol CLDN16.
- Organism: Homo sapiens.
- Length: 235 amino acids.
- Top disease associations (Open Targets): renal hypomagnesemia 3, Autosomal dominant primary hypomagnesemia with hypocalciuria and nephrocalcinosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Claudin-16 |
|---|---|
| UniProt accession | Q9Y5I7 |
| Gene | CLDN16 |
| Organism | Homo sapiens |
| Length | 235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- renal hypomagnesemia 3 · score 0.79
- Autosomal dominant primary hypomagnesemia with hypocalciuria · score 0.57
- nephrocalcinosis · score 0.27
- renal hypomagnesemia 5 with ocular involvement · score 0.27
- nephrolithiasis · score 0.26
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.23
- optic disc size measurement · score 0.22
- genetic disorder · score 0.19
- head and neck squamous cell carcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5I7-F1 | alphafold | PREDICTED | 77.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5I7.
Amino-acid sequence (235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLDN16?
The strongest Open Targets associations for CLDN16 are renal hypomagnesemia 3, Autosomal dominant primary hypomagnesemia with hypocalciuria, nephrocalcinosis, renal hypomagnesemia 5 with ocular involvement and nephrolithiasis.
How long is the CLDN16 protein?
The Homo sapiens CLDN16 protein (UniProt Q9Y5I7) is 235 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5I7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5I7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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