Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)
Homo sapiens — UniProt Q9Y5J3
Data last refreshed: (UniProt release unknown)
Key facts
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) is a protein from Homo sapiens identified by UniProt accession Q9Y5J3, 304 residues long. MolForge cross-references it against 0 known binders and 212 disease associations.
- UniProt accession: Q9Y5J3; gene symbol HEY1.
- Organism: Homo sapiens.
- Length: 304 amino acids.
- Top disease associations (Open Targets): mesenchymal chondrosarcoma, primary central chondrosarcoma and dedifferentiated chondrosarcoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hairy/enhancer-of-split related with YRPW motif protein 1 |
|---|---|
| UniProt accession | Q9Y5J3 |
| Gene | HEY1 |
| Organism | Homo sapiens |
| Length | 304 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (212)
Diseases linked to this target (Open Targets).
- mesenchymal chondrosarcoma · score 0.38
- primary central chondrosarcoma · score 0.37
- dedifferentiated chondrosarcoma · score 0.37
- neurodegenerative disease · score 0.37
- head and neck squamous cell carcinoma · score 0.35
- hepatocellular carcinoma · score 0.30
- esophageal squamous cell carcinoma · score 0.28
- lung adenocarcinoma · score 0.28
- gastric adenocarcinoma · score 0.28
- osteosarcoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5J3-F1 | alphafold | PREDICTED | 66.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5J3.
Amino-acid sequence (304 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HEY1?
The strongest Open Targets associations for HEY1 are mesenchymal chondrosarcoma, primary central chondrosarcoma, dedifferentiated chondrosarcoma, neurodegenerative disease and head and neck squamous cell carcinoma.
How long is the HEY1 protein?
The Homo sapiens HEY1 protein (UniProt Q9Y5J3) is 304 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5J3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5J3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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