Pleckstrin homology-like domain family A member 3 (PHLDA3)
Homo sapiens — UniProt Q9Y5J5
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology-like domain family A member 3 (PHLDA3) is a protein from Homo sapiens identified by UniProt accession Q9Y5J5, 127 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q9Y5J5; gene symbol PHLDA3.
- Organism: Homo sapiens.
- Length: 127 amino acids.
- Top disease associations (Open Targets): hair shape measurement, creatinine measurement and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology-like domain family A member 3 |
|---|---|
| UniProt accession | Q9Y5J5 |
| Gene | PHLDA3 |
| Organism | Homo sapiens |
| Length | 127 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- hair shape measurement · score 0.28
- creatinine measurement · score 0.28
- breast carcinoma · score 0.28
- balding measurement · score 0.28
- reactive cutaneous fibrous lesion · score 0.26
- FEV/FVC ratio · score 0.26
- ear malformation · score 0.10
- cardiac hypertrophy · score 0.07
- osteosarcoma · score 0.07
- head and neck squamous cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5J5-F1 | alphafold | PREDICTED | 89.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5J5.
Amino-acid sequence (127 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHLDA3?
The strongest Open Targets associations for PHLDA3 are hair shape measurement, creatinine measurement, breast carcinoma, balding measurement and reactive cutaneous fibrous lesion.
How long is the PHLDA3 protein?
The Homo sapiens PHLDA3 protein (UniProt Q9Y5J5) is 127 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5J5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5J5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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