Meiotic recombination protein SPO11 (SPO11)
Homo sapiens — UniProt Q9Y5K1
Data last refreshed: (UniProt release unknown)
Key facts
Meiotic recombination protein SPO11 (SPO11) is a protein from Homo sapiens identified by UniProt accession Q9Y5K1, 396 residues long. MolForge cross-references it against 0 known binders and 240 disease associations.
- UniProt accession: Q9Y5K1; gene symbol SPO11.
- Organism: Homo sapiens.
- Length: 396 amino acids.
- Top disease associations (Open Targets): azoospermia, erythrocyte count and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Meiotic recombination protein SPO11 |
|---|---|
| UniProt accession | Q9Y5K1 |
| Gene | SPO11 |
| Organism | Homo sapiens |
| Length | 396 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (240)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.29
- erythrocyte count · score 0.23
- head and neck squamous cell carcinoma · score 0.23
- breast adenocarcinoma · score 0.22
- lung adenocarcinoma · score 0.18
- hemoglobin measurement · score 0.14
- hematocrit · score 0.13
- partial chromosome Y deletion · score 0.09
- appendicular lean mass · score 0.09
- spermatogenic failures 50 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5K1-F1 | alphafold | PREDICTED | 90.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5K1.
Amino-acid sequence (396 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPO11?
The strongest Open Targets associations for SPO11 are azoospermia, erythrocyte count, head and neck squamous cell carcinoma, breast adenocarcinoma and lung adenocarcinoma.
How long is the SPO11 protein?
The Homo sapiens SPO11 protein (UniProt Q9Y5K1) is 396 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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