Choline-phosphate cytidylyltransferase B (PCYT1B)
Homo sapiens — UniProt Q9Y5K3
Data last refreshed: (UniProt release unknown)
Key facts
Choline-phosphate cytidylyltransferase B (PCYT1B) is a protein from Homo sapiens identified by UniProt accession Q9Y5K3, 369 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.
- UniProt accession: Q9Y5K3; gene symbol PCYT1B.
- Organism: Homo sapiens.
- Length: 369 amino acids.
- Top disease associations (Open Targets): neuroinflammatory disorder, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Choline-phosphate cytidylyltransferase B |
|---|---|
| UniProt accession | Q9Y5K3 |
| Gene | PCYT1B |
| Organism | Homo sapiens |
| Length | 369 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (167)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.27
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- Abdominal pain · score 0.16
- primary ovarian insufficiency · score 0.09
- 46,XX gonadal dysgenesis · score 0.09
- azoospermia · score 0.08
- neoplasm · score 0.08
- Testicular regression syndrome · score 0.07
- 46,XX testicular disorder of sex development · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5K3-F1 | alphafold | PREDICTED | 75.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5K3.
Amino-acid sequence (369 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCYT1B?
The strongest Open Targets associations for PCYT1B are neuroinflammatory disorder, glioblastoma multiforme, breast adenocarcinoma, Abdominal pain and primary ovarian insufficiency.
How long is the PCYT1B protein?
The Homo sapiens PCYT1B protein (UniProt Q9Y5K3) is 369 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5K3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5K3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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