Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5)
Homo sapiens — UniProt Q9Y5K5
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) is a protein from Homo sapiens identified by UniProt accession Q9Y5K5, 329 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.
- UniProt accession: Q9Y5K5; gene symbol UCHL5.
- Organism: Homo sapiens.
- Length: 329 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase isozyme L5 |
|---|---|
| UniProt accession | Q9Y5K5 |
| Gene | UCHL5 |
| Organism | Homo sapiens |
| Length | 329 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (82)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- body mass index · score 0.27
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- lymphocyte count · score 0.11
- neoplasm · score 0.09
- hepatocellular carcinoma · score 0.08
- chronic myelogenous leukemia · score 0.08
- urinary bladder carcinoma · score 0.07
- lung adenocarcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5K5-F1 | alphafold | PREDICTED | 90.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5K5.
Amino-acid sequence (329 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UCHL5?
The strongest Open Targets associations for UCHL5 are neurodegenerative disease, body mass index, ovarian cancer, breast adenocarcinoma and lymphocyte count.
How long is the UCHL5 protein?
The Homo sapiens UCHL5 protein (UniProt Q9Y5K5) is 329 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5K5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5K5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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