CD2-associated protein (CD2AP)
Homo sapiens — UniProt Q9Y5K6
Data last refreshed: (UniProt release unknown)
Key facts
CD2-associated protein (CD2AP) is a protein from Homo sapiens identified by UniProt accession Q9Y5K6, 639 residues long. MolForge cross-references it against 0 known binders and 266 disease associations.
- UniProt accession: Q9Y5K6; gene symbol CD2AP.
- Organism: Homo sapiens.
- Length: 639 amino acids.
- Top disease associations (Open Targets): focal segmental glomerulosclerosis, familial idiopathic steroid-resistant nephrotic syndrome and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CD2-associated protein |
|---|---|
| UniProt accession | Q9Y5K6 |
| Gene | CD2AP |
| Organism | Homo sapiens |
| Length | 639 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (266)
Diseases linked to this target (Open Targets).
- focal segmental glomerulosclerosis · score 0.66
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.64
- reticulocyte count · score 0.51
- Red cell distribution width · score 0.49
- Alzheimer disease · score 0.47
- mean platelet volume · score 0.46
- body height · score 0.46
- platelet count · score 0.43
- reticulocyte measurement · score 0.42
- family history of Alzheimer’s disease · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5K6-F1 | alphafold | PREDICTED | 62.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5K6.
Amino-acid sequence (639 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CD2AP?
The strongest Open Targets associations for CD2AP are focal segmental glomerulosclerosis, familial idiopathic steroid-resistant nephrotic syndrome, reticulocyte count, Red cell distribution width and Alzheimer disease.
How long is the CD2AP protein?
The Homo sapiens CD2AP protein (UniProt Q9Y5K6) is 639 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5K6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5K6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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