Transportin-3 (TNPO3)
Homo sapiens — UniProt Q9Y5L0
Data last refreshed: (UniProt release unknown)
Key facts
Transportin-3 (TNPO3) is a protein from Homo sapiens identified by UniProt accession Q9Y5L0, 923 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9Y5L0; gene symbol TNPO3.
- Organism: Homo sapiens.
- Length: 923 amino acids.
- Top disease associations (Open Targets): autosomal dominant limb-girdle muscular dystrophy type 1F, neurodegenerative disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transportin-3 |
|---|---|
| UniProt accession | Q9Y5L0 |
| Gene | TNPO3 |
| Organism | Homo sapiens |
| Length | 923 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- autosomal dominant limb-girdle muscular dystrophy type 1F · score 0.71
- neurodegenerative disease · score 0.52
- lysosomal storage disease · score 0.49
- multiple sclerosis · score 0.47
- Parkinson disease · score 0.46
- Alzheimer disease · score 0.46
- systemic lupus erythematosus · score 0.33
- systemic scleroderma · score 0.32
- primary biliary cirrhosis · score 0.28
- rheumatoid arthritis · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5L0-F1 | alphafold | PREDICTED | 94.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5L0.
Amino-acid sequence (923 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TNPO3?
The strongest Open Targets associations for TNPO3 are autosomal dominant limb-girdle muscular dystrophy type 1F, neurodegenerative disease, lysosomal storage disease, multiple sclerosis and Parkinson disease.
How long is the TNPO3 protein?
The Homo sapiens TNPO3 protein (UniProt Q9Y5L0) is 923 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5L0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5L0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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