Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2)
Homo sapiens — UniProt Q9Y5L3
Data last refreshed: (UniProt release unknown)
Key facts
Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) is a protein from Homo sapiens identified by UniProt accession Q9Y5L3, 495 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q9Y5L3; gene symbol ENTPD2.
- Organism: Homo sapiens.
- Length: 495 amino acids.
- Top disease associations (Open Targets): genetic disorder, neoplasm and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ectonucleoside triphosphate diphosphohydrolase 2 |
|---|---|
| UniProt accession | Q9Y5L3 |
| Gene | ENTPD2 |
| Organism | Homo sapiens |
| Length | 495 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.12
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.08
- experimental autoimmune encephalomyelitis · score 0.07
- neutrophil count · score 0.06
- cancer · score 0.04
- leukocyte count · score 0.04
- intrahepatic cholangiocarcinoma · score 0.03
- endometrial carcinoma · score 0.03
- Sepsis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5L3-F1 | alphafold | PREDICTED | 92.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5L3.
Amino-acid sequence (495 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ENTPD2?
The strongest Open Targets associations for ENTPD2 are genetic disorder, neoplasm, hepatocellular carcinoma, experimental autoimmune encephalomyelitis and neutrophil count.
How long is the ENTPD2 protein?
The Homo sapiens ENTPD2 protein (UniProt Q9Y5L3) is 495 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5L3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5L3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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