Signal recognition particle receptor subunit beta (SRPRB)
Homo sapiens — UniProt Q9Y5M8
Data last refreshed: (UniProt release unknown)
Key facts
Signal recognition particle receptor subunit beta (SRPRB) is a protein from Homo sapiens identified by UniProt accession Q9Y5M8, 271 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q9Y5M8; gene symbol SRPRB.
- Organism: Homo sapiens.
- Length: 271 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, alcohol drinking and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal recognition particle receptor subunit beta |
|---|---|
| UniProt accession | Q9Y5M8 |
| Gene | SRPRB |
| Organism | Homo sapiens |
| Length | 271 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- alcohol drinking · score 0.27
- mean corpuscular volume · score 0.27
- serum non-albumin protein measurement · score 0.25
- mean corpuscular hemoglobin concentration · score 0.24
- iron biomarker measurement · score 0.24
- erythrocyte count · score 0.22
- blood protein measurement · score 0.20
- serum iron measurement · score 0.19
- total iron binding capacity · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5M8-F1 | alphafold | PREDICTED | 86.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5M8.
Amino-acid sequence (271 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SRPRB?
The strongest Open Targets associations for SRPRB are neurodegenerative disease, alcohol drinking, mean corpuscular volume, serum non-albumin protein measurement and mean corpuscular hemoglobin concentration.
How long is the SRPRB protein?
The Homo sapiens SRPRB protein (UniProt Q9Y5M8) is 271 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5M8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5M8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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