Origin recognition complex subunit 6 (ORC6)
Homo sapiens — UniProt Q9Y5N6
Data last refreshed: (UniProt release unknown)
Key facts
Origin recognition complex subunit 6 (ORC6) is a protein from Homo sapiens identified by UniProt accession Q9Y5N6, 252 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9Y5N6; gene symbol ORC6.
- Organism: Homo sapiens.
- Length: 252 amino acids.
- Top disease associations (Open Targets): Ear-patella-short stature syndrome, neurodegenerative disease and microcephalic primordial dwarfism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Origin recognition complex subunit 6 |
|---|---|
| UniProt accession | Q9Y5N6 |
| Gene | ORC6 |
| Organism | Homo sapiens |
| Length | 252 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- Ear-patella-short stature syndrome · score 0.79
- neurodegenerative disease · score 0.52
- microcephalic primordial dwarfism · score 0.37
- age at menopause · score 0.27
- endometrial cancer · score 0.27
- lung adenocarcinoma · score 0.23
- Meier-Gorlin syndrome · score 0.19
- small cell lung carcinoma · score 0.19
- genetic disorder · score 0.18
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5N6-F1 | alphafold | PREDICTED | 81.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5N6.
Amino-acid sequence (252 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ORC6?
The strongest Open Targets associations for ORC6 are Ear-patella-short stature syndrome, neurodegenerative disease, microcephalic primordial dwarfism, age at menopause and endometrial cancer.
How long is the ORC6 protein?
The Homo sapiens ORC6 protein (UniProt Q9Y5N6) is 252 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5N6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5N6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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