Ceramide transfer protein (CERT1)
Homo sapiens — UniProt Q9Y5P4
Data last refreshed: (UniProt release unknown)
Key facts
Ceramide transfer protein (CERT1) is a protein from Homo sapiens identified by UniProt accession Q9Y5P4, 624 residues long. MolForge cross-references it against 0 known binders and 204 disease associations.
- UniProt accession: Q9Y5P4; gene symbol CERT1.
- Organism: Homo sapiens.
- Length: 624 amino acids.
- Top disease associations (Open Targets): intellectual disability, autosomal dominant, Intellectual disability and complex neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ceramide transfer protein |
|---|---|
| UniProt accession | Q9Y5P4 |
| Gene | CERT1 |
| Organism | Homo sapiens |
| Length | 624 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (204)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal dominant · score 0.45
- Intellectual disability · score 0.44
- complex neurodevelopmental disorder · score 0.37
- limb-girdle muscular dystrophy · score 0.34
- genetic disorder · score 0.34
- low density lipoprotein cholesterol measurement · score 0.34
- total cholesterol measurement · score 0.32
- Autistic behavior · score 0.26
- platelet count · score 0.25
- type 2 diabetes mellitus · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5P4-F1 | alphafold | PREDICTED | 76.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5P4.
Amino-acid sequence (624 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CERT1?
The strongest Open Targets associations for CERT1 are intellectual disability, autosomal dominant, Intellectual disability, complex neurodevelopmental disorder, limb-girdle muscular dystrophy and genetic disorder.
How long is the CERT1 protein?
The Homo sapiens CERT1 protein (UniProt Q9Y5P4) is 624 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5P4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5P4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.