About Ceramide transfer protein
Ceramide transfer protein (CERT1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y5P4, 624 residues long.
MolForge cross-references it against 0 known binders and
204 disease associations.
Target properties
| Protein name | Ceramide transfer protein |
|---|
| UniProt accession | Q9Y5P4 |
|---|
| Gene | CERT1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 624 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (204)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal dominant · score 0.45
- Intellectual disability · score 0.44
- complex neurodevelopmental disorder · score 0.37
- limb-girdle muscular dystrophy · score 0.34
- genetic disorder · score 0.34
- low density lipoprotein cholesterol measurement · score 0.34
- total cholesterol measurement · score 0.32
- Autistic behavior · score 0.26
- platelet count · score 0.25
- type 2 diabetes mellitus · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y5P4-F1 | alphafold | PREDICTED | 76.98 | — |
Amino-acid sequence (624 residues)
MSDNQSWNSS GSEEDPETES GPPVERCGVL SKWTNYIHGW QDRWVVLKNN ALSYYKSEDE TEYGCRGSIC LSKAVITPHD FDECRFDISV NDSVWYLRAQ DPDHRQQWID AIEQHKTESG YGSESSLRRH GSMVSLVSGA SGYSATSTSS FKKGHSLREK LAEMETFRDI LCRQVDTLQK YFDACADAVS KDELQRDKVV EDDEDDFPTT RSDGDFLHST NGNKEKLFPH VTPKGINGID FKGEAITFKA TTAGILATLS HCIELMVKRE DSWQKRLDKE TEKKRRTEEA YKNAMTELKK KSHFGGPDYE EGPNSLINEE EFFDAVEAAL DRQDKIEEQS QSEKVRLHWP TSLPSGDAFS SVGTHRFVQK PYSRSSSMSS IDLVSASDDV HRFSSQVEEM VQNHMTYSLQ DVGGDANWQL VVEEGEMKVY RREVEENGIV LDPLKATHAV KGVTGHEVCN YFWNVDVRND WETTIENFHV VETLADNAII IYQTHKRVWP ASQRDVLYLS VIRKIPALTE NDPETWIVCN FSVDHDSAPL NNRCVRAKIN VAMICQTLVS PPEGNQEISR DNILCKITYV ANVNPGGWAP ASVLRAVAKR EYPKFLKRFT SYVQEKTAGK PILF
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