Mannose-1-phosphate guanylyltransferase catalytic subunit beta (GMPPB)
Homo sapiens — UniProt Q9Y5P6
Data last refreshed: (UniProt release unknown)
Key facts
Mannose-1-phosphate guanylyltransferase catalytic subunit beta (GMPPB) is a protein from Homo sapiens identified by UniProt accession Q9Y5P6, 360 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.
- UniProt accession: Q9Y5P6; gene symbol GMPPB.
- Organism: Homo sapiens.
- Length: 360 amino acids.
- Top disease associations (Open Targets): autosomal recessive limb-girdle muscular dystrophy type 2T, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A14 and muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mannose-1-phosphate guanylyltransferase catalytic subunit beta |
|---|---|
| UniProt accession | Q9Y5P6 |
| Gene | GMPPB |
| Organism | Homo sapiens |
| Length | 360 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (102)
Diseases linked to this target (Open Targets).
- autosomal recessive limb-girdle muscular dystrophy type 2T · score 0.84
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A14 · score 0.79
- muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14 · score 0.77
- muscular dystrophy-dystroglycanopathy, type A · score 0.57
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.51
- Abnormality of the musculature · score 0.49
- myopathy caused by variation in GMPPB · score 0.44
- muscular dystrophy · score 0.43
- muscular dystrophy-dystroglycanopathy · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5P6-F1 | alphafold | PREDICTED | 96.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5P6.
Amino-acid sequence (360 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GMPPB?
The strongest Open Targets associations for GMPPB are autosomal recessive limb-girdle muscular dystrophy type 2T, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A14, muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14, muscular dystrophy-dystroglycanopathy, type A and neurodegenerative disease.
How long is the GMPPB protein?
The Homo sapiens GMPPB protein (UniProt Q9Y5P6) is 360 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5P6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5P6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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