Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PPP2R3B)
Homo sapiens — UniProt Q9Y5P8
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PPP2R3B) is a protein from Homo sapiens identified by UniProt accession Q9Y5P8, 575 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9Y5P8; gene symbol PPP2R3B.
- Organism: Homo sapiens.
- Length: 575 amino acids.
- Top disease associations (Open Targets): endometrial cancer, head and neck squamous cell carcinoma and melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta |
|---|---|
| UniProt accession | Q9Y5P8 |
| Gene | PPP2R3B |
| Organism | Homo sapiens |
| Length | 575 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- endometrial cancer · score 0.27
- head and neck squamous cell carcinoma · score 0.20
- melanoma · score 0.05
- neoplasm · score 0.01
- idiopathic scoliosis · score 0.01
- juvenile dermatomyositis · score 0.01
- large congenital melanocytic nevus · score 0.01
- Kyphoscoliosis · score 0.01
- cancer · score 0.00
- Intestinal epithelial dysplasia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5P8-F1 | alphafold | PREDICTED | 79.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5P8.
Amino-acid sequence (575 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP2R3B?
The strongest Open Targets associations for PPP2R3B are endometrial cancer, head and neck squamous cell carcinoma, melanoma, neoplasm and idiopathic scoliosis.
How long is the PPP2R3B protein?
The Homo sapiens PPP2R3B protein (UniProt Q9Y5P8) is 575 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5P8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5P8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.