Transcription factor MafB (MAFB)
Homo sapiens — UniProt Q9Y5Q3
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor MafB (MAFB) is a protein from Homo sapiens identified by UniProt accession Q9Y5Q3, 323 residues long. MolForge cross-references it against 0 known binders and 416 disease associations.
- UniProt accession: Q9Y5Q3; gene symbol MAFB.
- Organism: Homo sapiens.
- Length: 323 amino acids.
- Top disease associations (Open Targets): multicentric carpo-tarsal osteolysis with or without nephropathy, Duane retraction syndrome and Duane retraction syndrome 3 with or without deafness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor MafB |
|---|---|
| UniProt accession | Q9Y5Q3 |
| Gene | MAFB |
| Organism | Homo sapiens |
| Length | 323 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (416)
Diseases linked to this target (Open Targets).
- multicentric carpo-tarsal osteolysis with or without nephropathy · score 0.80
- Duane retraction syndrome · score 0.67
- Duane retraction syndrome 3 with or without deafness · score 0.61
- neurodegenerative disease · score 0.49
- monocyte count · score 0.44
- lymphocyte count · score 0.43
- leukocyte count · score 0.43
- triglyceride measurement · score 0.42
- myeloid white cell count · score 0.42
- low density lipoprotein cholesterol measurement · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Q3-F1 | alphafold | PREDICTED | 62.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Q3.
Amino-acid sequence (323 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAFB?
The strongest Open Targets associations for MAFB are multicentric carpo-tarsal osteolysis with or without nephropathy, Duane retraction syndrome, Duane retraction syndrome 3 with or without deafness, neurodegenerative disease and monocyte count.
How long is the MAFB protein?
The Homo sapiens MAFB protein (UniProt Q9Y5Q3) is 323 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Q3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Q3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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