Atrial natriuretic peptide-converting enzyme (CORIN)
Homo sapiens — UniProt Q9Y5Q5
Data last refreshed: (UniProt release unknown)
Key facts
Atrial natriuretic peptide-converting enzyme (CORIN) is a protein from Homo sapiens identified by UniProt accession Q9Y5Q5, 1042 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q9Y5Q5; gene symbol CORIN.
- Organism: Homo sapiens.
- Length: 1042 amino acids.
- Top disease associations (Open Targets): preeclampsia, cardiomyopathy, familial hypertrophic, 30, atrial and atrial fibrillation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Atrial natriuretic peptide-converting enzyme |
|---|---|
| UniProt accession | Q9Y5Q5 |
| Gene | CORIN |
| Organism | Homo sapiens |
| Length | 1042 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- preeclampsia · score 0.58
- cardiomyopathy, familial hypertrophic, 30, atrial · score 0.46
- atrial fibrillation · score 0.36
- hypertension · score 0.35
- hypertensive disorder · score 0.34
- cardiomyopathy · score 0.34
- Myocardial fibrosis · score 0.34
- breast adenocarcinoma · score 0.22
- genetic disorder · score 0.19
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Q5-F1 | alphafold | PREDICTED | 69.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Q5.
Amino-acid sequence (1042 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CORIN?
The strongest Open Targets associations for CORIN are preeclampsia, cardiomyopathy, familial hypertrophic, 30, atrial, atrial fibrillation, hypertension and hypertensive disorder.
How long is the CORIN protein?
The Homo sapiens CORIN protein (UniProt Q9Y5Q5) is 1042 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Q5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Q5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.