Insulin-like peptide INSL5 (INSL5)
Homo sapiens — UniProt Q9Y5Q6
Data last refreshed: (UniProt release unknown)
Key facts
Insulin-like peptide INSL5 (INSL5) is a protein from Homo sapiens identified by UniProt accession Q9Y5Q6, 135 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.
- UniProt accession: Q9Y5Q6; gene symbol INSL5.
- Organism: Homo sapiens.
- Length: 135 amino acids.
- Top disease associations (Open Targets): cutaneous melanoma, lung adenocarcinoma and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Insulin-like peptide INSL5 |
|---|---|
| UniProt accession | Q9Y5Q6 |
| Gene | INSL5 |
| Organism | Homo sapiens |
| Length | 135 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (146)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.18
- lung adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.17
- low grade glioma · score 0.14
- squamous cell lung carcinoma · score 0.12
- neoplasm · score 0.08
- polycystic ovary syndrome · score 0.08
- azoospermia · score 0.06
- primary ovarian insufficiency · score 0.05
- ulcerative colitis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Q6-F1 | alphafold | PREDICTED | 64.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Q6.
Amino-acid sequence (135 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with INSL5?
The strongest Open Targets associations for INSL5 are cutaneous melanoma, lung adenocarcinoma, breast adenocarcinoma, low grade glioma and squamous cell lung carcinoma.
How long is the INSL5 protein?
The Homo sapiens INSL5 protein (UniProt Q9Y5Q6) is 135 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Q6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Q6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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