General transcription factor 3C polypeptide 5 (GTF3C5)
Homo sapiens — UniProt Q9Y5Q8
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor 3C polypeptide 5 (GTF3C5) is a protein from Homo sapiens identified by UniProt accession Q9Y5Q8, 519 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9Y5Q8; gene symbol GTF3C5.
- Organism: Homo sapiens.
- Length: 519 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Intellectual disability and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor 3C polypeptide 5 |
|---|---|
| UniProt accession | Q9Y5Q8 |
| Gene | GTF3C5 |
| Organism | Homo sapiens |
| Length | 519 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- Intellectual disability · score 0.18
- Neurodevelopmental disorder · score 0.18
- eosinophil count · score 0.17
- eosinophil percentage of leukocytes · score 0.12
- blood protein measurement · score 0.11
- eosinophil percentage of granulocytes · score 0.09
- neutrophil percentage of granulocytes · score 0.09
- basophil count · score 0.08
- Red cell distribution width · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Q8-F1 | alphafold | PREDICTED | 77.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Q8.
Amino-acid sequence (519 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF3C5?
The strongest Open Targets associations for GTF3C5 are neurodegenerative disease, Intellectual disability, Neurodevelopmental disorder, eosinophil count and eosinophil percentage of leukocytes.
How long is the GTF3C5 protein?
The Homo sapiens GTF3C5 protein (UniProt Q9Y5Q8) is 519 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Q8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Q8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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