General transcription factor 3C polypeptide 3 (GTF3C3)
Homo sapiens — UniProt Q9Y5Q9
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor 3C polypeptide 3 (GTF3C3) is a protein from Homo sapiens identified by UniProt accession Q9Y5Q9, 886 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q9Y5Q9; gene symbol GTF3C3.
- Organism: Homo sapiens.
- Length: 886 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, chromosome 2q32-q33 deletion syndrome and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor 3C polypeptide 3 |
|---|---|
| UniProt accession | Q9Y5Q9 |
| Gene | GTF3C3 |
| Organism | Homo sapiens |
| Length | 886 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- chromosome 2q32-q33 deletion syndrome · score 0.27
- Intellectual disability · score 0.18
- Seizure · score 0.18
- Global developmental delay · score 0.18
- Neurodevelopmental disorder · score 0.12
- body fat percentage · score 0.02
- neoplasm · score 0.02
- Obesity · score 0.00
- Microcephaly · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Q9-F1 | alphafold | PREDICTED | 80.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Q9.
Amino-acid sequence (886 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF3C3?
The strongest Open Targets associations for GTF3C3 are neurodegenerative disease, chromosome 2q32-q33 deletion syndrome, Intellectual disability, Seizure and Global developmental delay.
How long is the GTF3C3 protein?
The Homo sapiens GTF3C3 protein (UniProt Q9Y5Q9) is 886 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Q9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Q9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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