MTRF1L release factor glutamine methyltransferase (HEMK1)
Homo sapiens — UniProt Q9Y5R4
Data last refreshed: (UniProt release unknown)
Key facts
MTRF1L release factor glutamine methyltransferase (HEMK1) is a protein from Homo sapiens identified by UniProt accession Q9Y5R4, 338 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q9Y5R4; gene symbol HEMK1.
- Organism: Homo sapiens.
- Length: 338 amino acids.
- Top disease associations (Open Targets): body mass index, body weight and serum gamma-glutamyl transferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | MTRF1L release factor glutamine methyltransferase |
|---|---|
| UniProt accession | Q9Y5R4 |
| Gene | HEMK1 |
| Organism | Homo sapiens |
| Length | 338 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- body mass index · score 0.20
- body weight · score 0.15
- serum gamma-glutamyl transferase measurement · score 0.13
- diastolic blood pressure · score 0.11
- cognitive function measurement · score 0.10
- systolic blood pressure · score 0.10
- mean reticulocyte volume · score 0.08
- low density lipoprotein cholesterol measurement · score 0.08
- forced expiratory volume · score 0.07
- platelet count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5R4-F1 | alphafold | PREDICTED | 87.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5R4.
Amino-acid sequence (338 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HEMK1?
The strongest Open Targets associations for HEMK1 are body mass index, body weight, serum gamma-glutamyl transferase measurement, diastolic blood pressure and cognitive function measurement.
How long is the HEMK1 protein?
The Homo sapiens HEMK1 protein (UniProt Q9Y5R4) is 338 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5R4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5R4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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