Doublesex- and mab-3-related transcription factor 2 (DMRT2)
Homo sapiens — UniProt Q9Y5R5
Data last refreshed: (UniProt release unknown)
Key facts
Doublesex- and mab-3-related transcription factor 2 (DMRT2) is a protein from Homo sapiens identified by UniProt accession Q9Y5R5, 561 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.
- UniProt accession: Q9Y5R5; gene symbol DMRT2.
- Organism: Homo sapiens.
- Length: 561 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, reticulocyte count and reticulocyte measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Doublesex- and mab-3-related transcription factor 2 |
|---|---|
| UniProt accession | Q9Y5R5 |
| Gene | DMRT2 |
| Organism | Homo sapiens |
| Length | 561 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (159)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.44
- reticulocyte count · score 0.44
- reticulocyte measurement · score 0.42
- type 2 diabetes mellitus · score 0.40
- triglyceride measurement · score 0.39
- forced expiratory volume · score 0.37
- serum alanine aminotransferase measurement · score 0.36
- high density lipoprotein cholesterol measurement · score 0.35
- Immature Reticulocyte Fraction Measurement · score 0.32
- BMI-adjusted hip circumference · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5R5-F1 | alphafold | PREDICTED | 53.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5R5.
Amino-acid sequence (561 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DMRT2?
The strongest Open Targets associations for DMRT2 are sex hormone-binding globulin measurement, reticulocyte count, reticulocyte measurement, type 2 diabetes mellitus and triglyceride measurement.
How long is the DMRT2 protein?
The Homo sapiens DMRT2 protein (UniProt Q9Y5R5) is 561 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5R5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5R5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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