Doublesex- and mab-3-related transcription factor 1 (DMRT1)
Homo sapiens — UniProt Q9Y5R6
Data last refreshed: (UniProt release unknown)
Key facts
Doublesex- and mab-3-related transcription factor 1 (DMRT1) is a protein from Homo sapiens identified by UniProt accession Q9Y5R6, 373 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.
- UniProt accession: Q9Y5R6; gene symbol DMRT1.
- Organism: Homo sapiens.
- Length: 373 amino acids.
- Top disease associations (Open Targets): Testicular Germ Cell Tumor, neurodegenerative disease and testicular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Doublesex- and mab-3-related transcription factor 1 |
|---|---|
| UniProt accession | Q9Y5R6 |
| Gene | DMRT1 |
| Organism | Homo sapiens |
| Length | 373 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (170)
Diseases linked to this target (Open Targets).
- Testicular Germ Cell Tumor · score 0.56
- neurodegenerative disease · score 0.53
- testicular carcinoma · score 0.48
- calcium measurement · score 0.45
- 46,XY sex reversal 4 · score 0.44
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.37
- blood phosphate measurement · score 0.32
- azoospermia · score 0.32
- uterine fibroid · score 0.31
- monocyte count · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5R6-F1 | alphafold | PREDICTED | 56.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5R6.
Amino-acid sequence (373 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DMRT1?
The strongest Open Targets associations for DMRT1 are Testicular Germ Cell Tumor, neurodegenerative disease, testicular carcinoma, calcium measurement and 46,XY sex reversal 4.
How long is the DMRT1 protein?
The Homo sapiens DMRT1 protein (UniProt Q9Y5R6) is 373 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5R6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5R6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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