Serine/threonine-protein kinase MRCK beta (CDC42BPB)
Homo sapiens — UniProt Q9Y5S2
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase MRCK beta (CDC42BPB) is a protein from Homo sapiens identified by UniProt accession Q9Y5S2, 1711 residues long. MolForge cross-references it against 4 known binders and 44 disease associations.
- UniProt accession: Q9Y5S2; gene symbol CDC42BPB.
- Organism: Homo sapiens.
- Length: 1711 amino acids.
- Top disease associations (Open Targets): Chilton-Okur-Chung neurodevelopmental syndrome, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase MRCK beta |
|---|---|
| UniProt accession | Q9Y5S2 |
| Gene | CDC42BPB |
| Organism | Homo sapiens |
| Length | 1711 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- Chilton-Okur-Chung neurodevelopmental syndrome · score 0.70
- neurodegenerative disease · score 0.46
- genetic disorder · score 0.41
- Neurodevelopmental disorder · score 0.31
- autism spectrum disorder · score 0.30
- Intellectual disability · score 0.23
- Global developmental delay · score 0.23
- Autistic behavior · score 0.23
- Seizure · score 0.23
- Atypical behavior · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5S2-F1 | alphafold | PREDICTED | 75.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5S2.
Amino-acid sequence (1711 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CDC42BPB?
The strongest Open Targets associations for CDC42BPB are Chilton-Okur-Chung neurodevelopmental syndrome, neurodegenerative disease, genetic disorder, Neurodevelopmental disorder and autism spectrum disorder.
How long is the CDC42BPB protein?
The Homo sapiens CDC42BPB protein (UniProt Q9Y5S2) is 1711 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5S2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5S2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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