NADPH oxidase 1 (NOX1)
Homo sapiens — UniProt Q9Y5S8
Data last refreshed: (UniProt release unknown)
Key facts
NADPH oxidase 1 (NOX1) is a protein from Homo sapiens identified by UniProt accession Q9Y5S8, 564 residues long. MolForge cross-references it against 0 known binders and 318 disease associations.
- UniProt accession: Q9Y5S8; gene symbol NOX1.
- Organism: Homo sapiens.
- Length: 564 amino acids.
- Top disease associations (Open Targets): neoplasm, hepatocellular carcinoma and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NADPH oxidase 1 |
|---|---|
| UniProt accession | Q9Y5S8 |
| Gene | NOX1 |
| Organism | Homo sapiens |
| Length | 564 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (318)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.11
- lung adenocarcinoma · score 0.10
- colon carcinoma · score 0.09
- melanoma · score 0.08
- primary biliary cirrhosis · score 0.08
- idiopathic pulmonary fibrosis · score 0.07
- head and neck squamous cell carcinoma · score 0.07
- pulmonary arterial hypertension · score 0.07
- inflammatory bowel disease · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5S8-F1 | alphafold | PREDICTED | 90.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5S8.
Amino-acid sequence (564 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NOX1?
The strongest Open Targets associations for NOX1 are neoplasm, hepatocellular carcinoma, lung adenocarcinoma, colon carcinoma and melanoma.
How long is the NOX1 protein?
The Homo sapiens NOX1 protein (UniProt Q9Y5S8) is 564 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5S8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5S8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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