RNA-binding protein 8A (RBM8A)
Homo sapiens — UniProt Q9Y5S9
Data last refreshed: (UniProt release unknown)
Key facts
RNA-binding protein 8A (RBM8A) is a protein from Homo sapiens identified by UniProt accession Q9Y5S9, 174 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q9Y5S9; gene symbol RBM8A.
- Organism: Homo sapiens.
- Length: 174 amino acids.
- Top disease associations (Open Targets): thrombocytopenia-absent radius syndrome, Thrombocytopenia - absent radius and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA-binding protein 8A |
|---|---|
| UniProt accession | Q9Y5S9 |
| Gene | RBM8A |
| Organism | Homo sapiens |
| Length | 174 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- thrombocytopenia-absent radius syndrome · score 0.75
- Thrombocytopenia - absent radius · score 0.64
- neurodegenerative disease · score 0.31
- Global developmental delay · score 0.27
- Clinodactyly of the 5th finger · score 0.27
- Abnormal brain morphology · score 0.27
- endometrial cancer · score 0.23
- genetic disorder · score 0.16
- hepatocellular carcinoma · score 0.10
- glioblastoma multiforme · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5S9-F1 | alphafold | PREDICTED | 80.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5S9.
Amino-acid sequence (174 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RBM8A?
The strongest Open Targets associations for RBM8A are thrombocytopenia-absent radius syndrome, Thrombocytopenia - absent radius, neurodegenerative disease, Global developmental delay and Clinodactyly of the 5th finger.
How long is the RBM8A protein?
The Homo sapiens RBM8A protein (UniProt Q9Y5S9) is 174 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5S9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5S9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.