Ubiquitin carboxyl-terminal hydrolase 16 (USP16)
Homo sapiens — UniProt Q9Y5T5
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 16 (USP16) is a protein from Homo sapiens identified by UniProt accession Q9Y5T5, 823 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9Y5T5; gene symbol USP16.
- Organism: Homo sapiens.
- Length: 823 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, breast adenocarcinoma and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 16 |
|---|---|
| UniProt accession | Q9Y5T5 |
| Gene | USP16 |
| Organism | Homo sapiens |
| Length | 823 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.23
- body height · score 0.21
- serum alanine aminotransferase measurement · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.16
- electrocardiography · score 0.11
- reticulocyte count · score 0.10
- body mass index · score 0.08
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.07
- body weight · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5T5-F1 | alphafold | PREDICTED | 66.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5T5.
Amino-acid sequence (823 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP16?
The strongest Open Targets associations for USP16 are glioblastoma multiforme, breast adenocarcinoma, body height, serum alanine aminotransferase measurement and serum gamma-glutamyl transferase measurement.
How long is the USP16 protein?
The Homo sapiens USP16 protein (UniProt Q9Y5T5) is 823 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5T5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5T5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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