Insulin-induced gene 2 protein (INSIG2)
Homo sapiens — UniProt Q9Y5U4
Data last refreshed: (UniProt release unknown)
Key facts
Insulin-induced gene 2 protein (INSIG2) is a protein from Homo sapiens identified by UniProt accession Q9Y5U4, 225 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.
- UniProt accession: Q9Y5U4; gene symbol INSIG2.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, heel bone mineral density and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Insulin-induced gene 2 protein |
|---|---|
| UniProt accession | Q9Y5U4 |
| Gene | INSIG2 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (165)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.47
- heel bone mineral density · score 0.42
- total cholesterol measurement · score 0.42
- bone quantitative ultrasound measurement · score 0.39
- apolipoprotein B measurement · score 0.39
- alcohol drinking · score 0.36
- alcohol consumption measurement · score 0.34
- neurodegenerative disease · score 0.34
- Varicose veins · score 0.31
- bone density · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5U4-F1 | alphafold | PREDICTED | 77.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5U4.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with INSIG2?
The strongest Open Targets associations for INSIG2 are low density lipoprotein cholesterol measurement, heel bone mineral density, total cholesterol measurement, bone quantitative ultrasound measurement and apolipoprotein B measurement.
How long is the INSIG2 protein?
The Homo sapiens INSIG2 protein (UniProt Q9Y5U4) is 225 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5U4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5U4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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