Tumor necrosis factor receptor superfamily member 18 (TNFRSF18)
Homo sapiens — UniProt Q9Y5U5
Data last refreshed: (UniProt release unknown)
Key facts
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) is a protein from Homo sapiens identified by UniProt accession Q9Y5U5, 241 residues long. MolForge cross-references it against 0 known binders and 254 disease associations.
- UniProt accession: Q9Y5U5; gene symbol TNFRSF18.
- Organism: Homo sapiens.
- Length: 241 amino acids.
- Top disease associations (Open Targets): neoplasm, drug use measurement and hypothyroidism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 18 |
|---|---|
| UniProt accession | Q9Y5U5 |
| Gene | TNFRSF18 |
| Organism | Homo sapiens |
| Length | 241 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (254)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.13
- drug use measurement · score 0.12
- hypothyroidism · score 0.10
- Miyoshi myopathy · score 0.10
- Systemic lupus erythematosus · score 0.09
- infect · score 0.09
- infection · score 0.09
- glioblastoma multiforme · score 0.08
- hair color · score 0.08
- squamous cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5U5-F1 | alphafold | PREDICTED | 74.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5U5.
Amino-acid sequence (241 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TNFRSF18?
The strongest Open Targets associations for TNFRSF18 are neoplasm, drug use measurement, hypothyroidism, Miyoshi myopathy and Systemic lupus erythematosus.
How long is the TNFRSF18 protein?
The Homo sapiens TNFRSF18 protein (UniProt Q9Y5U5) is 241 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5U5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5U5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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