Immediate early response 3-interacting protein 1 (IER3IP1)
Homo sapiens — UniProt Q9Y5U9
Data last refreshed: (UniProt release unknown)
Key facts
Immediate early response 3-interacting protein 1 (IER3IP1) is a protein from Homo sapiens identified by UniProt accession Q9Y5U9, 82 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9Y5U9; gene symbol IER3IP1.
- Organism: Homo sapiens.
- Length: 82 amino acids.
- Top disease associations (Open Targets): microcephaly, epilepsy, and diabetes syndrome, microcephaly, epilepsy, and diabetes syndrome 1 and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Immediate early response 3-interacting protein 1 |
|---|---|
| UniProt accession | Q9Y5U9 |
| Gene | IER3IP1 |
| Organism | Homo sapiens |
| Length | 82 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- microcephaly, epilepsy, and diabetes syndrome · score 0.68
- microcephaly, epilepsy, and diabetes syndrome 1 · score 0.66
- neurodegenerative disease · score 0.55
- Intellectual disability · score 0.37
- childhood epilepsy with centrotemporal spikes · score 0.33
- Rolandic epilepsy · score 0.33
- blood protein measurement · score 0.27
- lysosomal storage disease · score 0.24
- testosterone measurement · score 0.20
- age at menarche · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5U9-F1 | alphafold | PREDICTED | 61.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5U9.
Amino-acid sequence (82 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IER3IP1?
The strongest Open Targets associations for IER3IP1 are microcephaly, epilepsy, and diabetes syndrome, microcephaly, epilepsy, and diabetes syndrome 1, neurodegenerative disease, Intellectual disability and childhood epilepsy with centrotemporal spikes.
How long is the IER3IP1 protein?
The Homo sapiens IER3IP1 protein (UniProt Q9Y5U9) is 82 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5U9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5U9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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