Krueppel-like factor 2 (KLF2)
Homo sapiens — UniProt Q9Y5W3
Data last refreshed: (UniProt release unknown)
Key facts
Krueppel-like factor 2 (KLF2) is a protein from Homo sapiens identified by UniProt accession Q9Y5W3, 355 residues long. MolForge cross-references it against 0 known binders and 334 disease associations.
- UniProt accession: Q9Y5W3; gene symbol KLF2.
- Organism: Homo sapiens.
- Length: 355 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lymphocyte count and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Krueppel-like factor 2 |
|---|---|
| UniProt accession | Q9Y5W3 |
| Gene | KLF2 |
| Organism | Homo sapiens |
| Length | 355 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (334)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- lymphocyte count · score 0.45
- diastolic blood pressure · score 0.38
- Varicose veins · score 0.38
- leukocyte count · score 0.38
- lymphocyte percentage of leukocytes · score 0.38
- eosinophil count · score 0.35
- neutrophil percentage of leukocytes · score 0.31
- monocyte count · score 0.29
- eosinophil percentage of leukocytes · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5W3-F1 | alphafold | PREDICTED | 56.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5W3.
Amino-acid sequence (355 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLF2?
The strongest Open Targets associations for KLF2 are neurodegenerative disease, lymphocyte count, diastolic blood pressure, Varicose veins and leukocyte count.
How long is the KLF2 protein?
The Homo sapiens KLF2 protein (UniProt Q9Y5W3) is 355 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5W3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5W3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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