Wnt inhibitory factor 1 (WIF1)
Homo sapiens — UniProt Q9Y5W5
Data last refreshed: (UniProt release unknown)
Key facts
Wnt inhibitory factor 1 (WIF1) is a protein from Homo sapiens identified by UniProt accession Q9Y5W5, 379 residues long. MolForge cross-references it against 0 known binders and 364 disease associations.
- UniProt accession: Q9Y5W5; gene symbol WIF1.
- Organism: Homo sapiens.
- Length: 379 amino acids.
- Top disease associations (Open Targets): refractive error measurement, esophageal adenocarcinoma and breast ductal adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Wnt inhibitory factor 1 |
|---|---|
| UniProt accession | Q9Y5W5 |
| Gene | WIF1 |
| Organism | Homo sapiens |
| Length | 379 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (364)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.39
- esophageal adenocarcinoma · score 0.39
- breast ductal adenocarcinoma · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- lymphoid neoplasm · score 0.37
- bile duct carcinoma · score 0.37
- Salivary Gland Carcinoma ex Pleomorphic Adenoma · score 0.37
- Hepatobiliary Neoplasm · score 0.37
- Salivary Gland Pleomorphic Adenoma · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5W5-F1 | alphafold | PREDICTED | 79.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5W5.
Amino-acid sequence (379 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WIF1?
The strongest Open Targets associations for WIF1 are refractive error measurement, esophageal adenocarcinoma, breast ductal adenocarcinoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation and lymphoid neoplasm.
How long is the WIF1 protein?
The Homo sapiens WIF1 protein (UniProt Q9Y5W5) is 379 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5W5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5W5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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