Sorting nexin-14 (SNX14)
Homo sapiens — UniProt Q9Y5W7
Data last refreshed: (UniProt release unknown)
Key facts
Sorting nexin-14 (SNX14) is a protein from Homo sapiens identified by UniProt accession Q9Y5W7, 946 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q9Y5W7; gene symbol SNX14.
- Organism: Homo sapiens.
- Length: 946 amino acids.
- Top disease associations (Open Targets): autosomal recessive spinocerebellar ataxia 20, Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorting nexin-14 |
|---|---|
| UniProt accession | Q9Y5W7 |
| Gene | SNX14 |
| Organism | Homo sapiens |
| Length | 946 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- autosomal recessive spinocerebellar ataxia 20 · score 0.69
- Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome · score 0.69
- neurodegenerative disease · score 0.32
- Neurodevelopmental disorder · score 0.30
- Abnormal brain morphology · score 0.27
- cerebellar ataxia · score 0.26
- Global developmental delay · score 0.26
- Seizure · score 0.26
- heel bone mineral density · score 0.23
- myeloid white cell count · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5W7-F1 | alphafold | PREDICTED | 73.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5W7.
Amino-acid sequence (946 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNX14?
The strongest Open Targets associations for SNX14 are autosomal recessive spinocerebellar ataxia 20, Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome, neurodegenerative disease, Neurodevelopmental disorder and Abnormal brain morphology.
How long is the SNX14 protein?
The Homo sapiens SNX14 protein (UniProt Q9Y5W7) is 946 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5W7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5W7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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