Photoreceptor-specific nuclear receptor (NR2E3)
Homo sapiens — UniProt Q9Y5X4
Data last refreshed: (UniProt release unknown)
Key facts
Photoreceptor-specific nuclear receptor (NR2E3) is a protein from Homo sapiens identified by UniProt accession Q9Y5X4, 410 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.
- UniProt accession: Q9Y5X4; gene symbol NR2E3.
- Organism: Homo sapiens.
- Length: 410 amino acids.
- Target class: Nuclear receptor.
- Top disease associations (Open Targets): enhanced S-cone syndrome, retinitis pigmentosa 37 and retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Photoreceptor-specific nuclear receptor |
|---|---|
| UniProt accession | Q9Y5X4 |
| Gene | NR2E3 |
| Organism | Homo sapiens |
| Length | 410 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Nuclear receptor (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (183)
Diseases linked to this target (Open Targets).
- enhanced S-cone syndrome · score 0.81
- retinitis pigmentosa 37 · score 0.76
- retinitis pigmentosa · score 0.69
- Goldmann-Favre syndrome · score 0.61
- Retinal dystrophy · score 0.56
- Joubert syndrome and related disorders · score 0.51
- Cone rod dystrophy · score 0.43
- autosomal recessive retinitis pigmentosa · score 0.42
- Posterior column ataxia - retinitis pigmentosa · score 0.42
- cone-rod dystrophy · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5X4-F1 | alphafold | PREDICTED | 74.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5X4.
Amino-acid sequence (410 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NR2E3?
The strongest Open Targets associations for NR2E3 are enhanced S-cone syndrome, retinitis pigmentosa 37, retinitis pigmentosa, Goldmann-Favre syndrome and Retinal dystrophy.
How long is the NR2E3 protein?
The Homo sapiens NR2E3 protein (UniProt Q9Y5X4) is 410 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5X4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5X4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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