Endothelial lipase (LIPG)
Homo sapiens — UniProt Q9Y5X9
Data last refreshed: (UniProt release unknown)
Key facts
Endothelial lipase (LIPG) is a protein from Homo sapiens identified by UniProt accession Q9Y5X9, 500 residues long. MolForge cross-references it against 1 known binders and 225 disease associations.
- UniProt accession: Q9Y5X9; gene symbol LIPG.
- Organism: Homo sapiens.
- Length: 500 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, lipoprotein measurement and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endothelial lipase |
|---|---|
| UniProt accession | Q9Y5X9 |
| Gene | LIPG |
| Organism | Homo sapiens |
| Length | 500 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (225)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.72
- lipoprotein measurement · score 0.66
- total cholesterol measurement · score 0.65
- apolipoprotein A 1 measurement · score 0.64
- phospholipid measurement · score 0.59
- Red cell distribution width · score 0.56
- vitamin D measurement · score 0.53
- phosphatidylinositol measurement · score 0.52
- phosphatidylcholine measurement · score 0.52
- choline measurement · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5X9-F1 | alphafold | PREDICTED | 82.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5X9.
Amino-acid sequence (500 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LIPG?
The strongest Open Targets associations for LIPG are high density lipoprotein cholesterol measurement, lipoprotein measurement, total cholesterol measurement, apolipoprotein A 1 measurement and phospholipid measurement.
How long is the LIPG protein?
The Homo sapiens LIPG protein (UniProt Q9Y5X9) is 500 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5X9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5X9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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