Probable G-protein coupled receptor 45 (GPR45)
Homo sapiens — UniProt Q9Y5Y3
Data last refreshed: (UniProt release unknown)
Key facts
Probable G-protein coupled receptor 45 (GPR45) is a protein from Homo sapiens identified by UniProt accession Q9Y5Y3, 372 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q9Y5Y3; gene symbol GPR45.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): age at menarche, body height and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable G-protein coupled receptor 45 |
|---|---|
| UniProt accession | Q9Y5Y3 |
| Gene | GPR45 |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.39
- body height · score 0.37
- testosterone measurement · score 0.28
- metabolite measurement · score 0.02
- mean platelet volume · score 0.02
- Obesity · score 0.01
- cancer · score 0.01
- morbid obesity · score 0.01
- cone-rod dystrophy · score 0.00
- meningeal tuberculosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Y3-F1 | alphafold | PREDICTED | 83.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Y3.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR45?
The strongest Open Targets associations for GPR45 are age at menarche, body height, testosterone measurement, metabolite measurement and mean platelet volume.
How long is the GPR45 protein?
The Homo sapiens GPR45 protein (UniProt Q9Y5Y3) is 372 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Y3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Y3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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