Peroxisomal membrane protein PEX16 (PEX16)
Homo sapiens — UniProt Q9Y5Y5
Data last refreshed: (UniProt release unknown)
Key facts
Peroxisomal membrane protein PEX16 (PEX16) is a protein from Homo sapiens identified by UniProt accession Q9Y5Y5, 336 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9Y5Y5; gene symbol PEX16.
- Organism: Homo sapiens.
- Length: 336 amino acids.
- Top disease associations (Open Targets): Zellweger syndrome, peroxisome biogenesis disorder and peroxisome biogenesis disorder 8A (Zellweger).
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peroxisomal membrane protein PEX16 |
|---|---|
| UniProt accession | Q9Y5Y5 |
| Gene | PEX16 |
| Organism | Homo sapiens |
| Length | 336 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- Zellweger syndrome · score 0.78
- peroxisome biogenesis disorder · score 0.75
- peroxisome biogenesis disorder 8A (Zellweger) · score 0.75
- Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.74
- neurodegenerative disease · score 0.46
- peroxisome biogenesis disorder, complementation group 7 · score 0.37
- genetic disorder · score 0.19
- peroxisome biogenesis disorder 1A (Zellweger) · score 0.18
- SAPHO syndrome · score 0.12
- peroxisome biogenesis disorder due to PEX16 defect · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Y5-F1 | alphafold | PREDICTED | 82.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Y5.
Amino-acid sequence (336 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PEX16?
The strongest Open Targets associations for PEX16 are Zellweger syndrome, peroxisome biogenesis disorder, peroxisome biogenesis disorder 8A (Zellweger), Peroxisome biogenesis disorder-Zellweger syndrome spectrum and neurodegenerative disease.
How long is the PEX16 protein?
The Homo sapiens PEX16 protein (UniProt Q9Y5Y5) is 336 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Y5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Y5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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