Beta-secretase 2 (BACE2)
Homo sapiens — UniProt Q9Y5Z0
Data last refreshed: (UniProt release unknown)
Key facts
Beta-secretase 2 (BACE2) is a protein from Homo sapiens identified by UniProt accession Q9Y5Z0, 518 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.
- UniProt accession: Q9Y5Z0; gene symbol BACE2.
- Organism: Homo sapiens.
- Length: 518 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, body mass index and C-peptide measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-secretase 2 |
|---|---|
| UniProt accession | Q9Y5Z0 |
| Gene | BACE2 |
| Organism | Homo sapiens |
| Length | 518 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (169)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.35
- body mass index · score 0.35
- C-peptide measurement · score 0.33
- cognitive function measurement · score 0.26
- mathematical ability · score 0.26
- intelligence · score 0.24
- schizophrenia · score 0.24
- gastroesophageal reflux disease · score 0.20
- body height · score 0.19
- lymphocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Z0-F1 | alphafold | PREDICTED | 82.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Z0.
Amino-acid sequence (518 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BACE2?
The strongest Open Targets associations for BACE2 are self reported educational attainment, body mass index, C-peptide measurement, cognitive function measurement and mathematical ability.
How long is the BACE2 protein?
The Homo sapiens BACE2 protein (UniProt Q9Y5Z0) is 518 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Z0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Z0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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