Neuroplastin (NPTN)
Homo sapiens — UniProt Q9Y639
Data last refreshed: (UniProt release unknown)
Key facts
Neuroplastin (NPTN) is a protein from Homo sapiens identified by UniProt accession Q9Y639, 398 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q9Y639; gene symbol NPTN.
- Organism: Homo sapiens.
- Length: 398 amino acids.
- Top disease associations (Open Targets): serum gamma-glutamyl transferase measurement, FEV/FVC ratio and deafness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuroplastin |
|---|---|
| UniProt accession | Q9Y639 |
| Gene | NPTN |
| Organism | Homo sapiens |
| Length | 398 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.27
- FEV/FVC ratio · score 0.08
- deafness · score 0.07
- Stroke · score 0.07
- drug use measurement · score 0.06
- Autosomal recessive spastic paraplegia type 44 · score 0.04
- Paroxysmal exertion-induced dyskinesia · score 0.04
- atypical pantothenate kinase-associated neurodegeneration · score 0.04
- Stevens-Johnson syndrome · score 0.03
- toxic epidermal necrolysis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y639-F1 | alphafold | PREDICTED | 86.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y639.
Amino-acid sequence (398 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NPTN?
The strongest Open Targets associations for NPTN are serum gamma-glutamyl transferase measurement, FEV/FVC ratio, deafness, Stroke and drug use measurement.
How long is the NPTN protein?
The Homo sapiens NPTN protein (UniProt Q9Y639) is 398 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y639 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y639 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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