KICSTOR complex protein kaptin (KPTN)
Homo sapiens — UniProt Q9Y664
Data last refreshed: (UniProt release unknown)
Key facts
KICSTOR complex protein kaptin (KPTN) is a protein from Homo sapiens identified by UniProt accession Q9Y664, 436 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q9Y664; gene symbol KPTN.
- Organism: Homo sapiens.
- Length: 436 amino acids.
- Top disease associations (Open Targets): macrocephaly-developmental delay syndrome, genetic disorder and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | KICSTOR complex protein kaptin |
|---|---|
| UniProt accession | Q9Y664 |
| Gene | KPTN |
| Organism | Homo sapiens |
| Length | 436 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- macrocephaly-developmental delay syndrome · score 0.77
- genetic disorder · score 0.47
- Intellectual disability · score 0.27
- craniosynostosis · score 0.18
- Immunodeficiency due to a late component of complements deficiency · score 0.07
- mannose-binding lectin deficiency · score 0.06
- sex hormone-binding globulin measurement · score 0.05
- recurrent Neisseria infections due to factor D deficiency · score 0.05
- immunodeficiency 28 · score 0.05
- immunodeficiency 31B · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y664-F1 | alphafold | PREDICTED | 88.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y664.
Amino-acid sequence (436 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KPTN?
The strongest Open Targets associations for KPTN are macrocephaly-developmental delay syndrome, genetic disorder, Intellectual disability, craniosynostosis and Immunodeficiency due to a late component of complements deficiency.
How long is the KPTN protein?
The Homo sapiens KPTN protein (UniProt Q9Y664) is 436 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y664 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y664 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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