Protein O-mannosyl-transferase 1 (POMT1)
Homo sapiens — UniProt Q9Y6A1
Data last refreshed: (UniProt release unknown)
Key facts
Protein O-mannosyl-transferase 1 (POMT1) is a protein from Homo sapiens identified by UniProt accession Q9Y6A1, 747 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.
- UniProt accession: Q9Y6A1; gene symbol POMT1.
- Organism: Homo sapiens.
- Length: 747 amino acids.
- Top disease associations (Open Targets): muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1, autosomal recessive limb-girdle muscular dystrophy type 2K and muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein O-mannosyl-transferase 1 |
|---|---|
| UniProt accession | Q9Y6A1 |
| Gene | POMT1 |
| Organism | Homo sapiens |
| Length | 747 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (135)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 · score 0.83
- autosomal recessive limb-girdle muscular dystrophy type 2K · score 0.77
- muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1 · score 0.77
- muscular dystrophy-dystroglycanopathy, type A · score 0.67
- autosomal recessive limb-girdle muscular dystrophy · score 0.61
- limb-girdle muscular dystrophy-dystroglycanopathy, type c1 · score 0.57
- genetic disorder · score 0.51
- qualitative or quantitative defects of alpha-dystroglycan · score 0.47
- myopathy caused by variation in POMT1 · score 0.46
- Ventriculomegaly · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6A1-F1 | alphafold | PREDICTED | 87.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6A1.
Amino-acid sequence (747 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POMT1?
The strongest Open Targets associations for POMT1 are muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1, autosomal recessive limb-girdle muscular dystrophy type 2K, muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1, muscular dystrophy-dystroglycanopathy, type A and autosomal recessive limb-girdle muscular dystrophy.
How long is the POMT1 protein?
The Homo sapiens POMT1 protein (UniProt Q9Y6A1) is 747 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6A1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6A1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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