Cholesterol 24-hydroxylase (CYP46A1)
Homo sapiens — UniProt Q9Y6A2
Data last refreshed: (UniProt release unknown)
Key facts
Cholesterol 24-hydroxylase (CYP46A1) is a protein from Homo sapiens identified by UniProt accession Q9Y6A2, 500 residues long. MolForge cross-references it against 2 known binders and 120 disease associations.
- UniProt accession: Q9Y6A2; gene symbol CYP46A1.
- Organism: Homo sapiens.
- Length: 500 amino acids.
- Top disease associations (Open Targets): coronary artery disease, body fat percentage and Lennox-Gastaut syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cholesterol 24-hydroxylase |
|---|---|
| UniProt accession | Q9Y6A2 |
| Gene | CYP46A1 |
| Organism | Homo sapiens |
| Length | 500 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.35
- body fat percentage · score 0.28
- Lennox-Gastaut syndrome · score 0.26
- glioblastoma multiforme · score 0.19
- Myocardial Ischemia · score 0.18
- myocardial infarction · score 0.18
- coronary atherosclerosis · score 0.16
- coronary artery bypass · score 0.16
- pulse pressure measurement · score 0.14
- angina pectoris · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6A2-F1 | alphafold | PREDICTED | 94.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6A2.
Amino-acid sequence (500 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYP46A1?
The strongest Open Targets associations for CYP46A1 are coronary artery disease, body fat percentage, Lennox-Gastaut syndrome, glioblastoma multiforme and Myocardial Ischemia.
How long is the CYP46A1 protein?
The Homo sapiens CYP46A1 protein (UniProt Q9Y6A2) is 500 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6A2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6A2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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