Transforming acidic coiled-coil-containing protein 3 (TACC3)
Homo sapiens — UniProt Q9Y6A5
Data last refreshed: (UniProt release unknown)
Key facts
Transforming acidic coiled-coil-containing protein 3 (TACC3) is a protein from Homo sapiens identified by UniProt accession Q9Y6A5, 838 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.
- UniProt accession: Q9Y6A5; gene symbol TACC3.
- Organism: Homo sapiens.
- Length: 838 amino acids.
- Top disease associations (Open Targets): osteoarthritis, knee, serum gamma-glutamyl transferase measurement and urinary bladder carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transforming acidic coiled-coil-containing protein 3 |
|---|---|
| UniProt accession | Q9Y6A5 |
| Gene | TACC3 |
| Organism | Homo sapiens |
| Length | 838 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (167)
Diseases linked to this target (Open Targets).
- osteoarthritis, knee · score 0.31
- serum gamma-glutamyl transferase measurement · score 0.28
- urinary bladder carcinoma · score 0.26
- endometrial carcinoma · score 0.26
- mean reticulocyte volume · score 0.26
- body height · score 0.26
- blood protein measurement · score 0.24
- fibroblast growth factor receptor 3 measurement · score 0.24
- gait measurement · score 0.24
- lean body mass · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6A5-F1 | alphafold | PREDICTED | 56.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6A5.
Amino-acid sequence (838 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TACC3?
The strongest Open Targets associations for TACC3 are osteoarthritis, knee, serum gamma-glutamyl transferase measurement, urinary bladder carcinoma, endometrial carcinoma and mean reticulocyte volume.
How long is the TACC3 protein?
The Homo sapiens TACC3 protein (UniProt Q9Y6A5) is 838 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6A5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6A5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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