Signal peptidase complex subunit 1 (SPCS1)
Homo sapiens — UniProt Q9Y6A9
Data last refreshed: (UniProt release unknown)
Key facts
Signal peptidase complex subunit 1 (SPCS1) is a protein from Homo sapiens identified by UniProt accession Q9Y6A9, 169 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9Y6A9; gene symbol SPCS1.
- Organism: Homo sapiens.
- Length: 169 amino acids.
- Top disease associations (Open Targets): body height, osteoarthritis and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal peptidase complex subunit 1 |
|---|---|
| UniProt accession | Q9Y6A9 |
| Gene | SPCS1 |
| Organism | Homo sapiens |
| Length | 169 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- body height · score 0.09
- osteoarthritis · score 0.08
- body mass index · score 0.07
- blood protein measurement · score 0.07
- bipolar disorder · score 0.07
- schizophrenia · score 0.07
- BMI-adjusted waist circumference · score 0.06
- unipolar depression · score 0.06
- self reported educational attainment · score 0.06
- osteoarthritis, hip · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6A9-F1 | alphafold | PREDICTED | 63.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6A9.
Amino-acid sequence (169 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPCS1?
The strongest Open Targets associations for SPCS1 are body height, osteoarthritis, body mass index, blood protein measurement and bipolar disorder.
How long is the SPCS1 protein?
The Homo sapiens SPCS1 protein (UniProt Q9Y6A9) is 169 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6A9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6A9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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